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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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General Research Article

阿尔茨海默氏病：2,3-二磷酸甘油酸红细胞含量与循环促红细胞生成素

卷 16, 期 9, 2019

页: [834 - 835] 页: 2

弟呕挨: 10.2174/1567205016666190827120108

价格: $65

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摘要

背景：阿尔茨海默氏病（AD）的特征是β-淀粉样蛋白在红细胞中积累。 随后的红细胞损伤很可能会影响其携氧能力。 2,3-二磷酸甘油酸酯（2,3-DPG）与血红蛋白结合，从而促进氧气释放。 从理论上讲，AD中的2,3-DPG降低，并且产生的缺氧触发促红细胞生成素（EPO）释放。 方法与目的：为探讨这一理论，我们分析了AD，轻度认知障碍和对照组（主观认知障碍）中的红细胞2,3-DPG含量和EPO。 结果：我们研究了（i）红细胞中的2,3-DPG，以及（ii）AD中的循环EPO，两种标记均不受痴呆症的影响。 这些氧调节途径的紊乱似乎不参与AD的脑缺氧。

关键词: 阿尔茨海默病，2，3-二磷酸甘油酸酯，红细胞，促红细胞生成素，β-淀粉样蛋白，认知障碍。

« Previous Next »
[1]
Järemo P, Milovanovic M, Nilsson S, Buller C, Post C, Winblad B. Alzheimer’s disease is characterized by more low-density erythrocytes with increased volume and enhanced beta-amyloid x-40 content. J Intern Med 270(5): 489-92. (2011).
[2]
Järemo P, Jejcic A, Jelic V, Shahnaz T, Oweling M, Winblad B, et al. Alzheimer’s disease: Amyloid beta peptide isoform distributions in erythrocytes and in the cerebrospinal fluid show substantial similarities. Submitted (2019).
[3]
Kiko T, Nakagawa K, Satoh A, Tsuduki T, Furukawa K, Arai H, et al. Amyloid beta levels in human red blood cells. PLoS One 7(11)e49620 (2012).
[4]
Chang CY, Liang HJ, Chow SY, Chen SM, Liu DZ. Hemorheological mechanisms in Alzheimer′s disease. Microcirculation 14(6): 627-34. (2007).
[5]
Thomas HM, Lefrak SS, Irwin RS, Fritts RS, Caldwell PR. The oxyhemoglobin dissociation curve in health and disease. Role of 2,3-diphosphoglycerate. Am J Med 57(3): 331-48. (1974).
[6]
Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund LO, et al. Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J Intern Med 256(3): 240-6. (2004).
[7]
Sharma S, Brugnara C, Betensky RA, Waikar SS. Reductions in red blood cell 2,3-diphosphoglycerate concentration during continuous renal replacement therapy. Clin J Am Soc Nephrol 10(1): 74-9. (2015).
[8]
Kosenko EA, Aliev G, Kaminsky YG. Relationship between chronic disturbance of 2,3-diphosphoglycerate metabolism in erythrocytes and Alzheimer disease. CNS Neurol Disord Drug Targets 15(1): 113-23. (2016).

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