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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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General Research Article

HMPAO-SPECT可以区分具有或不具有认知缺陷的主观认知投诉和轻度认知障碍的患者

卷 16, 期 9, 2019

页: [843 - 851] 页: 9

弟呕挨: 10.2174/1567205016666190827115138

价格: $65

摘要

背景：越来越多的证据表明，导致阿尔茨海默氏病的病理过程逐渐发生，并在最早的临床症状出现之前的几十年开始发展。已经提出使用生物标记物来检测无症状受试者临床前阿尔茨海默氏病病理改变的证据。主观认知障碍（SCC），即具有正常认知能力的自我报告的认知能力下降已被报告为未来认知能力下降的指标，但是，这种情况并不明确。 目的：在本研究中，我们使用HMPAO-SPECT测量的区域性脑灌注作为神经退行性病变的生物标志物，以比较具有和没有最小认知功能障碍（分别为SCC +和SCC-）的主观认知障碍患者的区域性脑灌注。轻度认知障碍（MCI）。 方法：我们回顾性检查了736名因怀疑认知功能障碍而转诊至我们的记忆诊所的患者。排除患有明显痴呆症的患者后，自动定量评估10个前脑区域（丘脑，顶颞，内侧颞，后颞，后扣带回，每个区域左半球和右半球）的相对脑血流量，并对64 SCC进行神经心理学评估（分析了32位SCC +，32位SCC-）和28位MCI受试者。 结果：认知表现各组之间最相关的差异与言语记忆有关。左半球内侧颞区可以在所有三组之间明显地区分，从SCC向MCI的n灌注逐渐减少。左内侧颞区曲线下方的区域显示区分MCI和SCC的敏感性为0.61，特异性为0.78。 结论：对MCI和SCC +患者的HMPAO-SPECT数据进行的自动分析显示，内侧颞叶的灌注差异显着，言语记忆受损，这都是阿尔茨海默氏病的已知特征。与SCC-相比，SCC +中的灌注模式和言语记忆性能与MCI更相似。 因此，SPECT分析可以将那些灌注模式类似于MCI的受试者与那些没有灌注模式的受试者区分开。我们认为，这可以识别出具有发展为AD的风险不同的两个人群，SCC +受试者需要进一步的诊断检查和重复的随访。

关键词: SPECT，SCC，生物标志物，核成像，MCI，阿尔茨海默氏症。

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