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Research Article

镰状细胞性贫血患者白细胞介素IL1ß/ IL18和炎症小体NLRP1 / NLRP3多态性的频率及其与严重度评分的关系

卷 19, 期 10, 2019

页: [776 - 783] 页: 8

弟呕挨: 10.2174/1566524019666190826143749

价格: $65

摘要

背景：白介素IL1s / IL18和炎症小体NLRP1 / NLRP3多态性可以改变多种人类疾病的病程，既是传染性的，也是炎性的。这些蛋白的SNP与炎性体的建设性激活有关，并且IL-1β的过量产生会引起严重的自身炎症性疾病，如镰状细胞性贫血（SCA）。本研究旨在探讨亚马逊地区SCA患者白细胞介素IL1s / IL18与炎症小体NLRP1 / NLRP3多态性的关系及其与严重程度评分的关系。 方法：这项研究是在亚马逊河血友病医院（HEMOAM）进行的，其中21例被诊断为SCA（HbSS）的患者和50例健康捐赠者。通过聚合酶链反应-限制性片段长度多态性（PCR-RFLP）和实时PCR对白介素IL1s / IL18和炎性小体NLRP1 / NLRP3中的遗传多态性进行基因分型。进行了简单和多重逻辑回归分析，以研究多态性与SCA和严重评分之间的关联。 结果：C / C（IL18 -137G / C）和C / A（NLRP3，rs35829419）基因型似乎是SCA疾病的危险因素（IL18：G / G vs C / C OR = 103.500 [95％CI：8.32 -1287.79，p <0.00001]； IL18：G / G vs G / C OR = 7.360 [95％CI：0.85-63.48，p = 0.040]； IL18：G / G vs CC + CG OR = 14.481 [95％CI ：1.79-117.32，p ＝ 0.002； NLRP3：C / C与C / A：OR ＝ 10.967 [95％CI：2.41-49.89，p ＝ 0.0004]）。此外，只有等位基因C（IL18 -137G / C）和A（NLRP3）似乎是SCA疾病的危险因素（IL18：G vs C OR = 6.366 [95％CI：2.73-14.86，p <0.00001]; NLRP3 ：C vs A OR = 8.383 [95％CI：2.03-34.62，p = 0.005]。在基因型和等位基因与严重性评分之间未发现关联。 结论：描述了IL18（rs16944）和NLRP3（rs35829419）多态性与镰状细胞性贫血相关的证据。我们的结果表明，已评估基因型的个体与SCA疾病相关，即使它不影响严重评分。

关键词: SCA，多态性，促炎细胞因子，炎性体，白介素。

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