Synthesis and Reactivity of 7-Azaindoles (1H-Pyrrolo(2,3-b)pyridine)

Jean-Yves      Merour; Benoit      Joseph

doi:10.2174/1385272013375427

Abstract

The results of research into the chemistry of 7-azaindole during the last twenty years are presented. New synthetic methods for the 7-azaindole structures are developed including palladium-catalysed cross-coupling reactions. Reactivity of 3-formyl-, 3-halogeno- and 2-lithio-7-azaindole derivatives is reported. Functionalisation of the pyridine ring via the N-oxide is also described. In the last part, biological activity of various 7-azaindole derivatives is briefly indicated.

Keywords: Azaindoles, palladium-catalysed, cross-coupling reactions, Kirkpatrickia varialosa, pyrrolo annelation, heteroatomic rings, butylcarbonylaminopyridine, photo-Graebe-Ullmann, intramolecular cyclisation, iminophosphorane moiety., functionalised aldehyde, iodomethame, monobrominated

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Current Organic Chemistry

Title: Synthesis and Reactivity of 7-Azaindoles (1H-Pyrrolo(2,3-b)pyridine)

Volume: 5 Issue: 5

Author(s): Jean-Yves Merour and Benoit Joseph

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Abstract: The results of research into the chemistry of 7-azaindole during the last twenty years are presented. New synthetic methods for the 7-azaindole structures are developed including palladium-catalysed cross-coupling reactions. Reactivity of 3-formyl-, 3-halogeno- and 2-lithio-7-azaindole derivatives is reported. Functionalisation of the pyridine ring via the N-oxide is also described. In the last part, biological activity of various 7-azaindole derivatives is briefly indicated.

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Cite this article as:

Merour Jean-Yves and Joseph Benoit, Synthesis and Reactivity of 7-Azaindoles (1H-Pyrrolo(2,3-b)pyridine), Current Organic Chemistry 2001; 5 (5) . https://dx.doi.org/10.2174/1385272013375427

DOI https://dx.doi.org/10.2174/1385272013375427	Print ISSN 1385-2728
Publisher Name Bentham Science Publisher	Online ISSN 1875-5348

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