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Research Article

妊娠期自然杀伤细胞与滋养层细胞相互作用的特征

卷 20, 期 3, 2020

页: [202 - 219] 页: 18

弟呕挨: 10.2174/1566524019666190808103227

价格: $65

摘要

背景：母体自然杀伤细胞（NK细胞）是子宫胎盘床中盛行的白细胞种群。当前关于来自胎盘微环境的细胞因子对滋养层细胞和NK细胞受体表达的影响的描述是不充分和矛盾的。 NK细胞迁移通过滋养层细胞的能力的信息不足。 目的：评估健康妊娠中期和中期妊娠胎盘培养过程中获得的条件培养基对滋养层细胞和NK细胞表型的影响以及对滋养层细胞层NK细胞粘附和迁移的影响。 结果：我们确定从妊娠中期和晚期妊娠胎盘获得的条件培养基均能增加滋养层细胞CD106，CD49e，CD49a，CD31，CD51 / 61和整联蛋白β6的表达强度。从孕早期胎盘获得的条件培养基可增加NK细胞表达CD11a，CD29，CD49d，CD58，CD29的强度。来自妊娠晚期胎盘的条件培养基的存在导致NK细胞表达更强烈的CD29，CD49d，CD11a，CD29，CD49d和CD58。与存在早孕胎盘的条件培养基相比，在存在早孕胎盘的条件培养基中NK细胞通过滋养细胞的迁移增加了。这可能与NK细胞CD18的表达增加有关。 结论：孕早期的胎盘分泌产物增加了滋养层细胞和NK细胞的粘附受体表达。在这些条件下，滋养细胞能够确保NK细胞的粘附和迁移。

关键词: NK细胞，滋养细胞，迁移，粘附，受体，胎盘，NK-92，Jeg-3。

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