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General Review Article

在正常和病理条件下对胸腺素α的体外免疫检测

卷 27, 期 29, 2020

页: [4840 - 4854] 页: 15

弟呕挨: 10.2174/0929867326666190807145212

价格: $65

摘要

原胸腺素α（ProTα）是一种高酸性多肽，几乎在所有哺乳动物细胞和组织中普遍表达，由人类的109个氨基酸组成。 已知ProTα在细胞内既起抗凋亡和增殖介质的作用，又在细胞外起生物学反应的调节剂的作用，该调节剂介导类似于被称为“ alarmins”的分子的免疫应答。 ProTα的抗体和免疫化学技术在ProTα生物学作用的研究中发挥了主导作用，其几个方面仍然未知，并有助于弄清该多肽的诊断和治疗潜力。 这篇综述涉及迄今报道的抗体以及ProTα的相关免疫检测方法（免疫测定以及免疫组织化学，免疫细胞学，免疫印迹和免疫沉淀技术）及其在感兴趣的生物样品（组织提取物和切片，细胞，细胞裂解物，细胞培养上清液，体液）在健康和疾病状态。 在这种情况下，对文献信息进行了严格的讨论，并提出了一些结论性意见。

关键词: 胸腺肽α，抗体，免疫检测，免疫测定，免疫组化，免疫细胞学，免疫印迹，疾病生物标志物。

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