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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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General Research Article

日语版蒙特利尔认知评估与轻度认知障碍患者的PET影像学之间的关系

卷 16, 期 9, 2019

页: [852 - 860] 页: 9

弟呕挨: 10.2174/1567205016666190805155230

价格: $65

摘要

背景：蒙特利尔认知评估（MoCA）测试对检测轻度认知障碍或早期痴呆症具有很高的敏感性和特异性。然而，MoCA评分与正电子发射断层扫描成像结果如何相关尚不清楚。 目的：这项前瞻性研究探讨了轻度认知障碍受试者的日语版MoCA（MoCA-J）测试与脑淀粉样蛋白沉积或脑葡萄糖代谢之间的关系。 方法：共有125位轻度认知障碍受试者接受了MoCA-J测试，并进行了淀粉样和18F-氟脱氧葡萄糖正电子发射断层扫描。进行线性相关分析和多元线性回归分析，以研究MoCA-J评分与人口统计学特征，淀粉样蛋白沉积和脑葡萄糖代谢之间的关系。此外，统计参数映射8用于MoCA-J评分和脑葡萄糖代谢的体素智能回归分析。 结果：MoCA-J得分与年龄，受教育年限以及迷你精神状态检查得分显着相关。在对年龄，性别和教育程度进行调整后，MoCA-J评分与淀粉样蛋白保留率显着负相关（β= -0.174，p = 0.031），与脑葡萄糖代谢呈正相关（β= 0.183，p = 0.044）。统计参数映射显示，日语版的MoCA评分与双侧额叶和顶叶以及左侧前突的葡萄糖代谢相关。 结论：轻度认知障碍患者的总MoCA-J得分与淀粉样蛋白沉积以及额叶和顶叶葡萄糖代谢有关。我们的发现支持MoCA-J测试对筛查阿尔茨海默氏病高风险受试者的有用性。

关键词: 轻度认知障碍，前瞻性研究，日文版的蒙特利尔认知评估，淀粉样蛋白正电子发射断层显像，18F-氟脱氧葡萄糖-正电子发射断层显像，脑区。

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