Abstract
Cancer research has progressed leaps and bounds over the years. This review is a brief overview of the cancer research, milestone achievements and therapeutic studies on it over the one hundred ten years which would give us an insight into how far we have come to understand and combat this fatal disease leading to millions of deaths worldwide. Modern biology has proved that cancer is a very complex disease as still we do not know precisely how it triggers. It involves several factors such as protooncogene, oncogene, kinase, tumor suppressor gene, growth factor, signalling cascade, micro RNA, immunity, environmental factors and carcinogens. However, modern technology now helps the cancer patient on the basis of acquired and established knowledge in the last hundred years to save human lives.
Keywords: Anti-cancer, Cancer, Oncogene, Therapeutics, Tumour, Drug discovery, Drug Target, Medicinal Chemistry.
Graphical Abstract
[http://dx.doi.org/[DOI: 10.4236/jct.2016.710077]
[http://dx.doi.org/10.1038/35094086] [PMID: 11900254]
[http://dx.doi.org/10.1001/jama.1946.02870380008004] [PMID: 20997191]
[http://dx.doi.org/10.1039/C7NR09612G] [PMID: 29528075]
[http://dx.doi.org/10.1021/acs.bioconjchem.8b00750] [PMID: 30428665]
[http://dx.doi.org/10.1073/pnas.46.3.302] [PMID: 16578483]
[http://dx.doi.org/10.1200/JCO.2003.10.038] [PMID: 12748244]
[http://dx.doi.org/10.1200/JCO.2004.11.057] [PMID: 15310767]
[http://dx.doi.org/10.1126/science.2649981] [PMID: 2649981]
[http://dx.doi.org/10.1016/0092-8674(79)90205-8] [PMID: 229973]
[http://dx.doi.org/10.1073/pnas.77.3.1311] [PMID: 6246487]
[http://dx.doi.org/10.1038/334124a0] [PMID: 2968522]
[http://dx.doi.org/10.1038/342705a0] [PMID: 2531845]
[http://dx.doi.org/10.1016/0092-8674(90)90186-I] [PMID: 2188735]
[http://dx.doi.org/10.1126/science.3291120] [PMID: 3291120]
[http://dx.doi.org/10.1073/pnas.74.8.3171] [PMID: 269380]
[http://dx.doi.org/10.1016/0092-8674(77)90180-5] [PMID: 902310]
[http://dx.doi.org/10.1038/sj.onc.1202737] [PMID: 10445844]
[PMID: 4136142]
[http://dx.doi.org/10.1038/nature03552] [PMID: 15944707]
[http://dx.doi.org/10.1038/nature03702] [PMID: 15944708]
[http://dx.doi.org/10.1158/0008-5472.CAN-05-1783] [PMID: 16103053]
[PMID: 12264098]
[http://dx.doi.org/10.1126/science.67.1746.605-a] [PMID: 17792501]
[http://dx.doi.org/10.1126/science.124.3215.267] [PMID: 13351638]
[http://dx.doi.org/[doi: 10.1016/j.coi.2013.02.012]
[PMID: 4196138]
[http://dx.doi.org/10.7326/0003-4819-31-4-661] [PMID: 15392502]
[http://dx.doi.org/10.1073/pnas.14.9.714] [PMID: 16587397]
[http://dx.doi.org/10.1136/bmj.1.3622.1044] [PMID: 20775497]
[http://dx.doi.org/10.1042/bj0240497] [PMID: 16744388]
[PMID: 17247004]
[http://dx.doi.org/10.1016/0022-2836(78)90294-2] [PMID: 642006]
[http://dx.doi.org/10.1016/S0140-6736(03)12681-5] [PMID: 12642053]
[PMID: 12702558]
[PMID: 15395906]
[http://dx.doi.org/10.1084/jem.133.2.275] [PMID: 4332371]
[http://dx.doi.org/10.1084/jem.79.2.137] [PMID: 19871359]
[http://dx.doi.org/10.1001/jama.1946.02870380008004] [PMID: 20997191]
[http://dx.doi.org/10.1056/NEJM194806032382301] [PMID: 18860765]
[PMID: 14774407]
[http://dx.doi.org/10.1038/179663a0] [PMID: 13418758]
[http://dx.doi.org/10.1016/j.jaip.2017.03.015] [PMID: 28483313]
[http://dx.doi.org/10.1038/1681035a0] [PMID: 14910632]
[http://dx.doi.org/10.3181/00379727-76-18379] [PMID: 14816382]
[http://dx.doi.org/10.1002/1097-0142(195105)4:3<626:AID-CNCR2820040314>3.0.CO;2-1] [PMID: 14839617]
[http://dx.doi.org/10.3181/00379727-98-24205] [PMID: 13591363]
[http://dx.doi.org/10.1038/171737a0] [PMID: 13054692]
[http://dx.doi.org/10.1084/jem.97.5.695] [PMID: 13052828]
[http://dx.doi.org/10.3181/00379727-93-22757] [PMID: 13379512]
[http://dx.doi.org/10.1038/1841293a0] [PMID: 13819951]
[http://dx.doi.org/10.1038/1841648b0] [PMID: 13846363]
[http://dx.doi.org/[DOI: 10.1097/00007890-196301020-00004]
[http://dx.doi.org/10.1084/jem.122.3.467] [PMID: 4953873]
[http://dx.doi.org/10.1007/BF03256210] [PMID: 17154650]
[http://dx.doi.org/10.1007/s12094-006-0162-1] [PMID: 16632420]
[PMID: 8946930]
[http://dx.doi.org/10.1056/NEJMoa040938] [PMID: 15118073]
[http://dx.doi.org/10.1073/pnas.0405220101] [PMID: 15329413]
[http://dx.doi.org/10.1126/science.1101637] [PMID: 15284455]
[http://dx.doi.org/10.1093/jnci/djr060] [PMID: 21422402]
[http://dx.doi.org/10.1056/NEJMoa022457] [PMID: 12637609]
[http://dx.doi.org/10.1016/j.clinthera.2007.11.005] [PMID: 18158072]
[http://dx.doi.org/10.1158/1078-0432.CCR-07-5015] [PMID: 18593977]
[http://dx.doi.org/10.1038/leu.2008.334] [PMID: 19039322]
[http://dx.doi.org/10.1056/NEJMra044389] [PMID: 16014887]
[http://dx.doi.org/10.1080/1062936X.2010.548830] [PMID: 21400356]
[http://dx.doi.org/10.1073/pnas.47.10.1588] [PMID: 14479932]
[http://dx.doi.org/10.1136/bmj.2.5311.1019] [PMID: 14017064]
[http://dx.doi.org/10.1002/1097-0142(196305)16:5<616:AID-CNCR2820160512>3.0.CO;2-U] [PMID: 13939518]
[PMID: 5615176]
[http://dx.doi.org/10.1073/pnas.59.2.632] [PMID: 5238991]
[http://dx.doi.org/[DOI: 10.1039/C3RA45749D]
[PMID: 2673568]
[http://dx.doi.org/10.1016/S0092-8674(00)81683-9] [PMID: 10647931]
[http://dx.doi.org/10.1126/science.aaa6204] [PMID: 25838376]
[http://dx.doi.org/10.1016/j.canlet.2005.12.005] [PMID: 16413116]
[http://dx.doi.org/10.1021/acsomega.8b03308] [PMID: 30842983]
[http://dx.doi.org/10.1016/j.ctrv.2018.02.004] [PMID: 29502037]
[PMID: 5396222]
[PMID: 5533992]
[http://dx.doi.org/10.1016/0005-2736(76)90160-7] [PMID: 990323]
[http://dx.doi.org/10.1038/sj.onc.1206951] [PMID: 14576855]
[http://dx.doi.org/10.1586/14737140.7.4.447] [PMID: 17428165]
[http://dx.doi.org/10.1073/pnas.66.2.572] [PMID: 4317920]
[http://dx.doi.org/10.1038/2261211a0] [PMID: 4316301]
[http://dx.doi.org/10.1002/gcc.20266] [PMID: 16175572]
[http://dx.doi.org/10.7150/jca.21965] [PMID: 29290776]
[http://dx.doi.org/10.1038/225159a0] [PMID: 5409962]
[http://dx.doi.org/10.1073/pnas.66.2.352] [PMID: 5271168]
[http://dx.doi.org/10.1016/0022-2836(71)90420-7] [PMID: 5283752]
[http://dx.doi.org/10.1038/300706a0] [PMID: 6757758]
[http://dx.doi.org/10.1038/327031a0] [PMID: 3553962]
[http://dx.doi.org/10.1126/science.2683079] [PMID: 2683079]
[http://dx.doi.org/10.1172/JCI9054] [PMID: 10606615]
[http://dx.doi.org/10.1126/science.274.5293.1672] [PMID: 8939849]
[http://dx.doi.org/10.3892/ijo.16.5.871] [PMID: 10762622]
[http://dx.doi.org/10.1046/j.1365-2184.2003.00266.x] [PMID: 12814430]
[http://dx.doi.org/10.1073/pnas.68.4.820] [PMID: 5279523]
[http://dx.doi.org/10.1038/305779a0] [PMID: 6633649]
[http://dx.doi.org/10.1126/science.3983638] [PMID: 3983638]
[PMID: 4955705]
[http://dx.doi.org/10.1016/S0140-6736(72)91037-9] [PMID: 4113402]
[http://dx.doi.org/10.1038/bjc.1972.33] [PMID: 4561027]
[PMID: 8417787]
[PMID: 2648252]
[http://dx.doi.org/10.1038/nm0596-561] [PMID: 8616716]
[http://dx.doi.org/10.1007/BF00268415] [PMID: 4617159]
[http://dx.doi.org/10.1073/pnas.71.5.1743] [PMID: 4600264]
[http://dx.doi.org/10.1073/pnas.74.12.5463] [PMID: 271968]
[http://dx.doi.org/10.1016/S0076-6879(80)65059-9] [PMID: 6246368]
[http://dx.doi.org/10.1038/256495a0] [PMID: 1172191]
[http://dx.doi.org/10.1093/annonc/12.suppl_1.S49] [PMID: 11521722]
[http://dx.doi.org/10.1038/260170a0] [PMID: 176594]
[http://dx.doi.org/10.1073/pnas.75.9.4102] [PMID: 212733]
[http://dx.doi.org/10.1136/bmj.1.6075.1534-d] [PMID: 871651]
[http://dx.doi.org/10.1126/science.887927] [PMID: 887927]
[http://dx.doi.org/10.1093/jnci/60.4.819] [PMID: 633391]
[PMID: 427749]
[http://dx.doi.org/10.1016/0021-9681(82)90078-9] [PMID: 6282919]
[http://dx.doi.org/10.1016/0092-8674(82)90248-3] [PMID: 7139710]
[PMID: 3198229]
[http://dx.doi.org/10.1038/284067a0] [PMID: 6243750]
[PMID: 6159971]
[http://dx.doi.org/10.1016/0092-8674(80)90237-8] [PMID: 6156004]
[http://dx.doi.org/10.1038/301089a0] [PMID: 6185846]
[PMID: 3009002]
[http://dx.doi.org/10.1016/S0168-9525(99)01971-X] [PMID: 10729832]
[http://dx.doi.org/10.1158/1078-0432.CCR-08-2783] [PMID: 19509174]
[http://dx.doi.org/10.1158/1078-0432.CCR-06-2076] [PMID: 17363514]
[PMID: 6945905]
[PMID: 2941082]
[http://dx.doi.org/10.1073/pnas.72.1.11] [PMID: 1078892]
[http://dx.doi.org/10.1073/pnas.78.2.761] [PMID: 6262770]
[PMID: 6277904]
[http://dx.doi.org/10.1126/science.6823562] [PMID: 6823562]
[http://dx.doi.org/10.1126/science.2479986] [PMID: 2479986]
[http://dx.doi.org/10.1073/pnas.80.12.3812] [PMID: 6304740]
[http://dx.doi.org/10.1038/304602a0] [PMID: 6308473]
[http://dx.doi.org/10.1038/304596a0] [PMID: 6308472]
[http://dx.doi.org/10.1016/S0140-6736(84)91816-6] [PMID: 6145023]
[http://dx.doi.org/10.1126/science.6093263] [PMID: 6093263]
[http://dx.doi.org/10.1016/S0092-8674(85)80070-2] [PMID: 3924412]
[http://dx.doi.org/10.1016/0092-8674(86)90362-4] [PMID: 2875799]
[http://dx.doi.org/10.1038/335440a0] [PMID: 3262202]
[http://dx.doi.org/10.1016/0092-8674(89)90174-8] [PMID: 2649247]
[http://dx.doi.org/10.1038/348331a0] [PMID: 2250704]
[http://dx.doi.org/10.1016/0092-8674(85)90170-9] [PMID: 3907856]
[http://dx.doi.org/10.1038/323643a0] [PMID: 2877398]
[http://dx.doi.org/10.1126/science.3798106] [PMID: 3798106]
[http://dx.doi.org/10.1126/science.2270482] [PMID: 2270482]
[http://dx.doi.org/10.1038/350429a0] [PMID: 1672732]
[http://dx.doi.org/10.1038/350427a0] [PMID: 1849234]
[http://dx.doi.org/10.1016/0140-6736(91)92236-U] [PMID: 1682737]
[PMID: 8302019]
[http://dx.doi.org/10.1093/jnci/90.18.1371] [PMID: 9747868]
[http://dx.doi.org/10.1074/jbc.273.22.13375] [PMID: 9593664]
[http://dx.doi.org/10.1073/pnas.95.23.13513] [PMID: 9811831]
[http://dx.doi.org/10.1038/35888] [PMID: 9486653]
[http://dx.doi.org/10.1038/onc.2008.245] [PMID: 18794884]
[http://dx.doi.org/10.1016/j.gde.2009.11.002] [PMID: 20006486]
[http://dx.doi.org/10.1517/14728222.2011.644788] [PMID: 22239433]
[http://dx.doi.org/10.1083/jcb.119.2.301] [PMID: 1400575]
[http://dx.doi.org/10.1042/bj0600604] [PMID: 13249955]
[http://dx.doi.org/10.1038/nrm1666] [PMID: 15928714]
[http://dx.doi.org/10.1038/nrc.2017.53] [PMID: 28751651]
[http://dx.doi.org/10.1016/j.pharmthera.2011.03.009] [PMID: 21440002]
[http://dx.doi.org/10.1073/pnas.95.23.13726] [PMID: 9811868]
[http://dx.doi.org/10.1126/science.282.5391.1145] [PMID: 9804556]
[http://dx.doi.org/10.1200/JCO.1998.16.8.2659] [PMID: 9704716]
[http://dx.doi.org/10.1056/NEJM200103153441101] [PMID: 11248153]
[http://dx.doi.org/10.1093/carcin/bgq191] [PMID: 20852150]
[http://dx.doi.org/10.1056/NEJMoa032691] [PMID: 15175435]
[http://dx.doi.org/10.1016/S0140-6736(04)17398-4] [PMID: 15541448]
[http://dx.doi.org/10.1016/S1470-2045(05)70101-7] [PMID: 15863374]
[http://dx.doi.org/10.1056/NEJM200104053441401] [PMID: 11287972]
[http://dx.doi.org/10.1126/science.1058040] [PMID: 11181995]
[http://dx.doi.org/10.1038/35057062] [PMID: 11237011]
[http://dx.doi.org/10.1126/science.1087706] [PMID: 14512629]
[http://dx.doi.org/10.1056/NEJMoa030288] [PMID: 12826635]
[http://dx.doi.org/10.1081/CNV-120030218] [PMID: 15199612]
[http://dx.doi.org/10.1038/nature06008] [PMID: 17603471]
[http://dx.doi.org/10.1038/nature07056] [PMID: 18509334]
[http://dx.doi.org/10.1016/j.cell.2012.06.013] [PMID: 22770212]
[http://dx.doi.org/10.1038/nature04186] [PMID: 16341007]
[http://dx.doi.org/10.1016/j.ccr.2006.08.009] [PMID: 16959615]
[http://dx.doi.org/10.1158/0008-5472.CAN-06-3948] [PMID: 17638899]
[http://dx.doi.org/10.1038/nature11824] [PMID: 23376950]
[http://dx.doi.org/10.1038/nature05945] [PMID: 17625570]
[http://dx.doi.org/10.1056/NEJMoa0800251] [PMID: 18565862]
[http://dx.doi.org/10.1038/nm.2011] [PMID: 19701205]
[http://dx.doi.org/10.1038/nm.2020] [PMID: 19701203]
[http://dx.doi.org/10.1038/ng.109] [PMID: 18385676]
[http://dx.doi.org/10.1002/gcc.20600] [PMID: 18663749]
[http://dx.doi.org/10.1038/onc.2009.238] [PMID: 19684619]
[http://dx.doi.org/10.1016/j.ccr.2009.10.023] [PMID: 19962666]
[http://dx.doi.org/10.1016/j.ccr.2009.08.020] [PMID: 19800579]
[http://dx.doi.org/10.1056/NEJMoa1007478] [PMID: 20979473]
[http://dx.doi.org/10.1056/NEJMoa1006448] [PMID: 20979469]
[http://dx.doi.org/10.1016/j.ccr.2010.11.033] [PMID: 21156280]
[http://dx.doi.org/10.1038/bjc.2011.177] [PMID: 21610706]
[http://dx.doi.org/10.1158/1940-6207.CAPR-11-0143] [PMID: 21636543]
[http://dx.doi.org/10.1158/2159-8274.CD-10-0010] [PMID: 22586319]
[http://dx.doi.org/10.1158/1940-6207.CAPR-10-0376] [PMID: 21636548]
[http://dx.doi.org/10.1038/nature10983] [PMID: 22522925]
[http://dx.doi.org/10.1016/j.ccr.2012.01.007] [PMID: 22439937]
[http://dx.doi.org/10.1016/j.bbrc.2012.10.036] [PMID: 23068101]
[http://dx.doi.org/10.1038/emboj.2011.416] [PMID: 22085929]
[http://dx.doi.org/10.1172/JCI64048] [PMID: 23143308]
[http://dx.doi.org/10.1016/j.molcel.2013.02.018] [PMID: 23523371]
[http://dx.doi.org/10.1016/j.cell.2013.04.055] [PMID: 23706743]
[http://dx.doi.org/10.1111/nyas.12180] [PMID: 23772560]
[http://dx.doi.org/10.2217/imt.13.9] [PMID: 23444951]
[http://dx.doi.org/10.1126/science.1225829] [PMID: 22745249]
[http://dx.doi.org/10.1038/nbt.3235] [PMID: 25961408]
[http://dx.doi.org/10.1126/scitranslmed.aac5415] [PMID: 26333935]
[http://dx.doi.org/10.1038/nrclinonc.2016.36] [PMID: 27000958]
[http://dx.doi.org/10.5041/RMMJ.10179] [PMID: 25717386]
[http://dx.doi.org/10.1038/nature15742] [PMID: 26633636]
[http://dx.doi.org/10.1056/NEJMoa1113205] [PMID: 22397650]
[http://dx.doi.org/10.1038/nrc.2016.2] [PMID: 26822578]
[http://dx.doi.org/10.1038/nrc3239] [PMID: 22437870]
[http://dx.doi.org/10.1097/MCO.0b013e328361dc70] [PMID: 23676683]